---
title: "Using association plot"
author: "NEST CoreDev"
output: rmarkdown::html_vignette
runtime: shiny
vignette: >
  %\VignetteIndexEntry{Using association plot}
  %\VignetteEngine{knitr::rmarkdown}
  %\VignetteEncoding{UTF-8}
---

# `teal` application to use association plot with various datasets types

This vignette will guide you through the four parts to create a `teal` application using various types of datasets using the association plot module `tm_g_association()`:

1.  Load libraries
2.  Create data sets
3.  Create an `app` variable
4.  Run the app

## 1 - Load libraries

```{r echo=TRUE, message=FALSE, warning=FALSE, results="hide"}
library(teal.modules.general) # used to create the app
library(dplyr) # used to modify data sets
```

## 2 - Create data sets

Inside this app 4 datasets will be used

1.  `ADSL` A wide data set with subject data
2.  `ADRS` A long data set with response data for subjects at different time points of the study
3.  `ADTTE` A long data set with time to event data
4.  `ADLB` A long data set with lab measurements for each subject

```{r echo=TRUE, message=FALSE, warning=FALSE, results="hide"}
data <- teal_data()
data <- within(data, {
  ADSL <- teal.modules.general::rADSL %>%
    mutate(TRTDUR = round(as.numeric(TRTEDTM - TRTSDTM), 1))
  ADRS <- teal.modules.general::rADRS
  ADTTE <- teal.modules.general::rADTTE
  ADLB <- teal.modules.general::rADLB %>%
    mutate(CHGC = as.factor(case_when(
      CHG < 1 ~ "N",
      CHG > 1 ~ "P",
      TRUE ~ "-"
    )))
})
datanames <- c("ADSL", "ADRS", "ADTTE", "ADLB")
datanames(data) <- datanames
join_keys(data) <- default_cdisc_join_keys[datanames]
```

## 3 - Create an `app` variable

This is the most important section. We will use the `teal::init()` function to create an app. The data will be handed over using `teal.data::teal_data()`. The app itself will be constructed by multiple calls of `tm_g_association()` using different combinations of data sets.

```{r echo=TRUE, message=FALSE, warning=FALSE, results="hide"}
# configuration for a single wide dataset
mod1 <- tm_g_association(
  label = "Single wide dataset",
  ref = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADSL"]]),
      selected = "AGE",
      fixed = FALSE
    )
  ),
  vars = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variables:",
      choices = variable_choices(data[["ADSL"]]),
      selected = "BMRKR1",
      multiple = TRUE,
      fixed = FALSE
    )
  )
)

# configuration for two wide datasets
mod2 <- tm_g_association(
  label = "Two wide datasets",
  ref = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADSL"]], c("AGE", "SEX", "STRATA1", "RACE")),
      selected = "STRATA1",
      multiple = FALSE,
      fixed = FALSE
    )
  ),
  vars = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      label = "Select variables:",
      choices = variable_choices(data[["ADSL"]], c("AGE", "SEX", "RACE", "COUNTRY")),
      selected = c("AGE", "COUNTRY", "RACE"),
      multiple = TRUE,
      fixed = FALSE
    )
  )
)

# configuration for multiple long datasets
mod3 <- tm_g_association(
  label = "Multiple different long datasets",
  ref = data_extract_spec(
    dataname = "ADTTE",
    select = select_spec(
      label = "Select variables:",
      choices = variable_choices(data[["ADTTE"]]),
      selected = "AVAL",
      multiple = FALSE,
      fixed = FALSE
    ),
    filter = filter_spec(
      label = "Select endpoint:",
      vars = "PARAMCD",
      choices = value_choices(data[["ADTTE"]], "PARAMCD", "PARAM"),
      selected = c("PFS", "EFS"),
      multiple = TRUE
    )
  ),
  vars = data_extract_spec(
    dataname = "ADRS",
    reshape = TRUE,
    select = select_spec(
      label = "Select variable:",
      choices = variable_choices(data[["ADRS"]], c("AVALC", "BMRKR1", "BMRKR2", "ARM")),
      selected = "AVALC",
      multiple = TRUE,
      fixed = FALSE
    ),
    filter = list(
      filter_spec(
        label = "Select endpoints:",
        vars = "PARAMCD",
        choices = value_choices(data[["ADRS"]], "PARAMCD", "PARAM"),
        selected = "BESRSPI",
        multiple = TRUE
      ),
      filter_spec(
        label = "Select endpoints:",
        vars = "AVISIT",
        choices = levels(data[["ADRS"]]$AVISIT),
        selected = "SCREENING",
        multiple = TRUE
      )
    )
  )
)

# configuration for wide and long datasets
mod4 <- tm_g_association(
  label = "Wide and long datasets",
  ref = data_extract_spec(
    dataname = "ADRS",
    select = select_spec(
      choices = variable_choices(data[["ADRS"]], c("AVAL", "AVALC")),
      selected = "AVALC",
      multiple = FALSE,
      fixed = FALSE,
      label = "Selected variable:"
    ),
    filter = list(
      filter_spec(
        vars = "PARAMCD",
        choices = value_choices(data[["ADRS"]], "PARAMCD", "PARAM"),
        selected = levels(data[["ADRS"]]$PARAMCD),
        multiple = TRUE,
        label = "Select response"
      ),
      filter_spec(
        vars = "AVISIT",
        choices = levels(data[["ADRS"]]$AVISIT),
        selected = levels(data[["ADRS"]]$AVISIT),
        multiple = TRUE,
        label = "Select visit:"
      )
    )
  ),
  vars = data_extract_spec(
    dataname = "ADSL",
    select = select_spec(
      choices = variable_choices(data[["ADSL"]], c("SEX", "AGE", "RACE", "COUNTRY", "BMRKR1", "STRATA1", "ARM")),
      selected = "AGE",
      multiple = TRUE,
      fixed = FALSE,
      label = "Select variable:"
    )
  )
)

# configuration for the same long dataset (same subsets)
mod5 <- tm_g_association(
  label = "Same long datasets (same subsets)",
  ref = data_extract_spec(
    dataname = "ADRS",
    select = select_spec(
      choices = variable_choices(data[["ADRS"]]),
      selected = "AVALC",
      multiple = FALSE,
      fixed = FALSE,
      label = "Select variable:"
    )
  ),
  vars = data_extract_spec(
    dataname = "ADRS",
    select = select_spec(
      choices = variable_choices(data[["ADRS"]]),
      selected = "PARAMCD",
      multiple = TRUE,
      fixed = FALSE,
      label = "Select variable:"
    )
  )
)

# configuration for the same long dataset (different subsets)
mod6 <- tm_g_association(
  label = "Same long datasets (different subsets)",
  ref = data_extract_spec(
    dataname = "ADLB",
    filter = list(
      filter_spec(
        vars = "PARAMCD",
        choices = value_choices(data[["ADLB"]], "PARAMCD", "PARAM"),
        selected = levels(data[["ADLB"]]$PARAMCD)[1],
        multiple = FALSE,
        label = "Select lab:"
      ),
      filter_spec(
        vars = "AVISIT",
        choices = levels(data[["ADLB"]]$AVISIT),
        selected = levels(data[["ADLB"]]$AVISIT)[1],
        multiple = FALSE,
        label = "Select visit:"
      )
    ),
    select = select_spec(
      choices = variable_choices(data[["ADLB"]], c("AVAL", "CHG2", "PCHG2")),
      selected = "AVAL",
      multiple = FALSE
    )
  ),
  vars = data_extract_spec(
    dataname = "ADLB",
    filter = list(
      filter_spec(
        vars = "PARAMCD",
        choices = value_choices(data[["ADLB"]], "PARAMCD", "PARAM"),
        selected = levels(data[["ADLB"]]$PARAMCD)[1],
        multiple = FALSE,
        label = "Select labs:"
      ),
      filter_spec(
        vars = "AVISIT",
        choices = levels(data[["ADLB"]]$AVISIT),
        selected = levels(data[["ADLB"]]$AVISIT)[1],
        multiple = FALSE,
        label = "Select visit:"
      )
    ),
    select = select_spec(
      choices = variable_choices(data[["ADLB"]]),
      selected = "STRATA1",
      multiple = TRUE
    )
  )
)

# initialize the app
app <- init(
  data = data,
  modules = modules(
    # tm_g_association ----
    modules(
      label = "Association plot",
      mod1,
      mod2,
      mod3,
      mod4,
      mod5,
      mod6
    )
  )
)
```

## 4 - Run the app

A simple `shiny::shinyApp()` call will let you run the app. Note that app is only displayed when running this code inside an `R` session.

```{r, echo=TRUE, results="hide"}
shinyApp(app$ui, app$server, options = list(height = 1024, width = 1024))
```

<img src="images/app-using-association-plot.png" style="display: block; margin: 0px; width: 100%"/>